Seems your WSUS has a problem. Maybe the database or the IIS did crash. Check your servers firewall.
Restart your Server.
If it doesnt help, try this:
Check the log: C:\Windows\WID\Log\error.log
Try this:
"C:\Program Files\Update Services\Tools\wsusutil.exe" postinstall /servicing
Or this:
Activate and install „HTTP Activation“ @ „WCF Services“ on „.NET Framework 4.5 Features“.