First do: https://bytesandbones.wordpress.com/2018/02/22/debian-disabling-the-spooky-network-manager/
Then edit /etc/network/interfaces like:
# This file describes the network interfaces available on your system # and how to activate them. For more information, see interfaces(5). source /etc/network/interfaces.d/* # The loopback network interface auto lo iface lo inet loopback iface enp1s0f0 inet manual auto br0 iface br0 inet static address 192.168.100.xxx netmask 255.255.0.0 gateway 192.168.100.x dns-nameservers 192.168.100.x 8.8.8.8 dns-search domain.local bridge_ports enp1s0f0 bridge_stp off bridge_fd 0 bridge_maxwait 0 auto enp1s0f1 iface enp1s0f1 inet static address 10.81.100.xxx netmask 255.255.0.0 #gateway 10.81.100.x dns-nameservers 192.168.100.x 8.8.8.8 dns-search domain.local # END